In Search of Thoreau’s Flowers: An Exploration of Change and Loss is an immersive multidisciplinary experience that marries art and science through a modern artistic interpretation of Henry David Thoreau’s preserved plants. Thoreau was prolific in his practice of collecting botanical samples and plants are important indicators of how our world is responding to climate change. Long preserved in the Harvard University Herbaria, 648 specimens serve as the foundation of this new exhibition. The digitization of the specimens, and others in the Herbaria collection, are now allowing broader access to scholars and citizen scientists, in turn welcoming new domains of scholarship.